Adenosine diphosphate and the measurement of platelet adhesiveness

Adenosine diphosphate and the measurement of platelet adhesiveness.

Platelet adhesiveness to glass beads was measured in citrated blood at intervals up to two hours after the addition of adenosine diphosphate (A.D.P.). Adhesiveness increased for 15 minutes, fell towards the original level, and then steadily increased. The initial changes were associated with the formation and subsequent dispersal of platelet clumps. The sequence of events resembled the reported...

Platelet adhesiveness: the effect of centrifugation on the measurement of adhesiveness in platelet-rich plasma.

Platelet adhesiveness has been measured in citrated whole blood and in platelet-rich plasma obtained from normal subjects, splenectomized patients, and from patients in whom the diagnosis of recurrent venous thrombosis had been made. The duration of centrifugation used in the preparation of platelet-rich plasma was found to have a profound effect on the measurement of platelet adhesiveness beca...

Adenosine diphosphate-induced platelet aggregation in the states of hypercoagulability.

One hundred and seven patients with congestive heart failure, myocardial infarction and arteriosclerotic heart disease were studied by adenosine diphosphate-induced platelet aggregation, fibrinogen levels and ethanol gelation test. Both increases and decreases in platelet aggregation were observed. A significantly high percentage of patients showed a decreased platelet aggregation which was esp...

Platelet adhesiveness.

Platelet Adhesiveness

By MURRAY WEINER, M.D., KURT ZELTMACHER, M.D., CARL REICH, M.D., AND SHEPARD SHAPIRO, M.D. I N 1941, Helen Wright’ described a method for estimating the adhesive quality of platelets. Confirmation of the original findings by Spooner and Meyer’ established the procedure as a means of distinguishing this property of platelets. It is the purpose of the present report to evaluate the usefulness of ...